Simple Search Results

4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol AMODIAQUINE BDBM50041457 med.21724, Compound 188 CHEMBL682
CHEMBL1235 N-Monodesethylamodiaquine (Deaq) desethylamodiaquine 4-(7-Chloro-quinolin-4-ylamino)-2-ethylaminomethyl-phenol BDBM50056190 Monodesethylamodiaquine bidesethylamodiaquine Desethyl amodiaquine
US9527857, M BDBM253921 US9464092, M
BDBM204122 US9539260, M US9763952, Example M
BDBM256611 US9790174, Example 85(m) US10435361, Example 85(m) US9481648, 85(m)
US11267820, Compound m US10689395, Compound m BDBM448086
1,3-xylene 1,3-Dimethylbenzol m-methyltoluene BDBM50008556 m-xylene CHEMBL286727 m-Xylol 3-xylene meta-xylene m-dimethylbenzene

ChEMBL_692839 (CHEMBL1637353) Inhibition of human CYP2C8 using amodiaquine as a substrate
ChEBML_1683158 Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate
ChEMBL_1435702 (CHEMBL3388335) Inhibition of CYP2C8 (unknown origin) using amodiaquine substrate
ChEMBL_1667013 (CHEMBL4016809) Inhibition of human liver microsomes CYP2C8 using amodiaquine as substrate
ChEMBL_1981694 (CHEMBL4614956) Inhibition of CYP2C8 (unknown origin) assessed as reduction in amodiaquine N-deethylation
ChEMBL_2100789 (CHEMBL4809185) Direct inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate
ChEMBL_2265891 Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS analysis
ChEMBL_2252748 (CHEMBL5166958) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate in presence or absence of NADPH
ChEMBL_2282759 Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS/MS analysis
ChEMBL_2290734 Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS/MS analysis
ChEMBL_1824050 (CHEMBL4323814) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS/MS analysis
ChEMBL_1825000 (CHEMBL4324764) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS/MS analysis
ChEMBL_1832034 (CHEMBL4332042) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS/MS analysis
ChEMBL_1979600 (CHEMBL4612735) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS/MS analysis
ChEMBL_2022413 (CHEMBL4676226) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS/MS analysis
ChEMBL_2110155 (CHEMBL4818830) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS/MS analysis
ChEMBL_2165290 (CHEMBL5050151) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS/MS analysis
ChEMBL_2200574 (CHEMBL5113090) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate by LC-MS/MS analysis
ChEMBL_2100799 (CHEMBL4809195) Time-dependent inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate preincubated for 30 mins
ChEMBL_2296117 Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate in presence of NADPH by LC-MS/MS analysis
ChEBML_1695898 Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate after 10 mins by LC-MS/MS analysis
ChEMBL_1526170 (CHEMBL3636695) Reversible inhibition of CYP2C8 amodiaquine-N-deethylase activity in human liver microsomes by LC-MS/MS analysis
ChEMBL_2278018 Inhibition of CYP2C8 in human liver microsome suspension using amodiaquine substrate incubated for 30 mins by LC/MS analysis
ChEMBL_1486160 (CHEMBL3533279) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate after 5 mins by LC-MS/MS analysis
ChEMBL_2030249 (CHEMBL4684407) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate incubated for 30 mins by LC-MS/MS analysis
ChEMBL_2035469 (CHEMBL4689627) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate incubated for 15 mins by LC-MS/MS analysis
ChEMBL_2101773 (CHEMBL4810169) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate substrate in presence of NADPH by LC-MS/MS analysis
ChEMBL_1904192 (CHEMBL4406414) Inhibition of CYP2C8 in human pooled liver microsomes using amodiaquine as substrate after 10 mins by UPLC-MS/MS analysis
ChEMBL_2073304 (CHEMBL4728838) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate measured after 15 mins by LC-MS/MS analysis
ChEMBL_1742656 (CHEMBL4158406) Inhibition of of CYP2C8 in human liver microsomes using amodiaquine as substrate after 10 mins in presence of NADPH by LC-MS/MS analysis
ChEMBL_1920112 (CHEMBL4422957) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate after 15 mins in presence of NADPH by LC-MS/MS analysis
ChEMBL_2209733 (CHEMBL5122682) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate preincubated with compound followed by NADPH addition by LC-MS/MS analysis
ChEMBL_1586832 (CHEMBL3826664) Inhibition of CYP2C8 in human liver microsomes in presence of NADPH using amodiaquine as substrate measured within 2.5 mins by LC-MS/MS analysis
ChEMBL_1658365 (CHEMBL4007977) Inhibition of microsomal CYP2C8 (unknown origin) using amodiaquine as substrate preincubated for 5 mins followed by NADPH addition by LC-MS/MS analysis
ChEMBL_2277113 Inhibition of CYP2C8 (unknown origin) using amodiaquine as substrate incubated for 10 to 20 mins in presence of NADPH-generating system by LC-MS/MS analysis
ChEMBL_2291487 Inhibition of CYP2C8 in pooled human liver microsomes using amodiaquine as substrate assessed as reduction in N-desethylamodiaquine metabolite formation by LC-MS/MS analysis
ChEMBL_2017917 (CHEMBL4671495) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate incubated for 15 mins in presence of NADPH generating system by LC-MS/MS analysis
ChEMBL_2194838 (CHEMBL5107198) Inhibition of CYP2C8 in human liver microsomes at 10 uM using amodiaquine as substrate preincubated for 10 mins followed by NADPH addition by LC/MS analysis
Cytochrome P450 2C9 Inhibition Assay (Amodiaquine) The inhibition of cytochrome P450 2C8-isoenzyme catalysed deethylation of Amodiaquine by the test compound is assayed at 37° C. with human liver microsomes. All assays are carried out on a robotic system in 96 well plates. The final incubation volume contains TRIS buffer (0.1 M), MgCl2 (5 mM), human liver microsomes (0.05 mg/ml), Amodiaquine (1 uM) and the test compound at five different concentrations or no compound (high control) in duplicate (e.g. highest concentration 10-50 uM with subsequent serial 1:4 dilutions). Following a short preincubation period, reactions are started with the cofactor (NADPH, 1 mM) and stopped by cooling the incubation down to 8° C. and subsequently by addition of one volume of acetonitrile.
ChEBML_1688704 Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate preincubated for 15 mins measured after 8 mins in presence or absence of NADPH by LC/MS/MS analysis
ChEMBL_823394 (CHEMBL2046053) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate incubated for 3 mins prior to NAPDH-addition measured after 30 mins by RP-HPLC analysis
ChEMBL_1845026 (CHEMBL4345453) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 to 30 mins by LC-MS/MS analysis
ChEMBL_1902236 (CHEMBL4404458) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate preincubated for 5 mins followed by NADPH addition and measured for 10 to 30 mins by LC-MS/MS analysis
ChEMBL_2248277 (CHEMBL5162487) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as a substrate preincubated for 10 mins followed by NADPH addition and measured after 10 mins by LC/MS/MS analysis
Inhibition Assays The final incubation volume contains TRIS buffer (0.1 M), MgCl2 (5 mM), a certain concentration of human liver microsomes dependent on the P450 isoenzyme measured (P450 2C9, P450 3A4: 0.1 mg/ml; P450 2D6: 0.2 mg/ml; P450 2C19: 0.5 mg/ml; P450 2C8: 0.05 mg/ml) and a certain concentration of the individual substrate for each isoenzyme (P450 2C9: Diclofenac 10 μM; P450 3A4: Midazolam 5 μM; P450 2D6: Dextromethorphan 5 μM; P450 2C19: S-Mephenytoin 70 μM; P450 2C8: Amodiaquine 1 μM).
ChEMBL_1735367 (CHEMBL4150903) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate preincubated for 5 mins followed by addition of NADPH-regenerating system and measured after 15 mins by UPLC-MS analysis
ChEMBL_1904187 (CHEMBL4406409) Inhibition of CYP2C8 in human pooled liver microsomes using amodiaquine as substrate preincubated with NADPH for 30 mins followed by substrate addition and measured after 10 mins by UPLC-MS/MS analysis
ChEMBL_2080679 (CHEMBL4736470) Inhibition of CYP2C8 in human liver microsomes using amodiaquine as substrate preincubated for 10 mins in presence of NADPH generating system followed by substrate addition and measured after 10 mins by LC-MS/MS analysis

Query String: M AMODIAQUINE